α-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors.
نویسندگان
چکیده
As part of continued efforts to understand the mechanisms of 1,5-α-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.
منابع مشابه
Expression and characterization of a GH43 endo-arabinanase from Thermotoga thermarum
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 34 شماره
صفحات -
تاریخ انتشار 2011